The Bears weren’t able to come away with a victory in Week 9 against the Dolphins, but there are reasons for optimism in Chicago after Justin Fields set an NFL record for rushing yards by a quarterback in a regular-season game. Now, the Bears will take on the Lions, who are coming off a surprisingly dominant defensive performance against the Packers. The Bears are favored by three at home in the latest Week 10 NFL odds from Caesars Sportsbook, but who will win a battle between a newly-confident offense and a newly-confident defense? Which teams should you target in your NFL survivor picks and NFL office pool picks? All of the Week 10 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting advice and predictions you need to make the best Week 10 NFL picks now.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 of the 2022 NFL season on an incredible 151-108 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 10 NFL odds and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 10 NFL predictions

One of the model’s strongest Week 10 NFL picks is that the Titans (-2.5) cover the spread at home against the Broncos almost 60% of the time. Tennessee saw its five-game winning streak snapped with an overtime loss to the Chiefs in Week 9, but they’ve been able to hide rookie quarterback Malik Willis’ inexperience with a dominant run game.

Derrick Henry has rushed for 334 yards and four touchdowns in the two games since Willis entered the starting lineup and he’s topped the 100-yard mark in five consecutive games. There’s a chance that Ryan Tannehill (ankle) could return to the lineup this week to give the Tennessee offense a little more balance but even if Willis remains the starter, the Titans should be able to control the line of scrimmage.

Denver has the No. 2 defense in the NFL this season, but traded away Bradley Chubb at the deadline and have been getting torched on the ground in recent weeks. Jacksonville rushed for 191 yards against the Broncos in London and ranks 27th in the league in yards allowed per carry (4.9). The model predicts that Henry rushes for nearly 100 yards on average and that Tennessee covers in well over 50% of simulations. See which other teams to pick here.

Top Week 10 NFL survivor picks

The model’s Week 10 NFL knockout pool picks say to avoid the avoid the Saints, even though they are favorites over the Steelers. New Orleans is coming off a short week after playing on Monday and will visit a Steelers team coming off a bye. Rest means more in football than in any other sport, and Pittsburgh will have an eight-day advantage in that regard.

New Orleans has also lost back-to-back road games to teams with a combined 5-13 record. As for Pittsburgh, its last home game was its upset win over the Buccaneers, and the team could get back reigning Defensive Player of the Year T.J. Watt. Few players on either side of the ball affect their team more so than Watt, as Pittsburgh is 52-24-2 (.684) when he plays compared to 1-10 (.090) when he doesn’t. Given New Orleans’ struggles away from the Superdome, the model is avoiding the Saints in Week 10 NFL survivor pool picks. See which team you should pick here.

Top Week 10 NFL office pool picks

One of the strongest Week 10 NFL football pool picks from the model is that the Giants beat the Texans. While Houston will be coming off a mini-bye after playing last Thursday, New York is coming off a traditional bye after having Week 9 off. The Giants will have the rest advantage as well as the historical edge, as they’ve won four straight meetings against the Texans.

Houston has lost three straight games this season, and those defeats have come by an average of 12.3 points. It’s hard to see a path to victory for a Texans team that ranks 29th in total offense and 30th in total defense. Saquon Barkley is projected to have 94 rushing yards and 34 receiving yards. New York is also projected to have multiple takeaways and multiple sacks, which will be too much for Houston’s offense to overcome. See which other teams to pick here.

How to make Week 10 NFL picks 

The model has also made the call on who wins and covers in every other game on the Week 10 NFL schedule, and it also says a Super Bowl contender goes down hard. It’s also backing a shocking team in its NFL survivor picks. You can only get every pick for every game at SportsLine.

So what NFL predictions, NFL pool picks, and NFL survivor picks can you make with confidence? And which Super Bowl contender goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned more than $7,000 since its inception, and find out.

Week 10 NFL odds, lines, spreads

Get full NFL picks at SportsLine

Thursday, Nov. 10

Falcons at Panthers (+2.5, 42.5)

Featured Game | Carolina Panthers vs. Atlanta Falcons

Sunday, Nov. 13

Seahawks at Buccaneers (-3, 44.5)

Featured Game | Tampa Bay Buccaneers vs. Seattle Seahawks

Vikings at Bills (-3.5, 43.5)

Featured Game | Buffalo Bills vs. Minnesota Vikings

Lions at Bears (-3, 48.5)

Featured Game | Chicago Bears vs. Detroit Lions

Jaguars at Chiefs (-9.5, 50.5)

Featured Game | Kansas City Chiefs vs. Jacksonville Jaguars

Browns at Dolphins (-3.5, 48.5)

Featured Game | Miami Dolphins vs. Cleveland Browns

Texans at Giants (-4.5, 40.5)

Featured Game | New York Giants vs. Houston Texans

Saints at Steelers (+1.5, 40)

Featured Game | Pittsburgh Steelers vs. New Orleans Saints

Broncos at Titans (-2.5, 36.5)

Featured Game | Tennessee Titans vs. Denver Broncos

Colts at Raiders (-6, 42.5)

Featured Game | Las Vegas Raiders vs. Indianapolis Colts

Cowboys at Packers (+4.5, 43)

Featured Game | Green Bay Packers vs. Dallas Cowboys

Cardinals at Rams (-1.5, 41)

Featured Game | Los Angeles Rams vs. Arizona Cardinals

Chargers at 49ers (-7, 45.5)

Featured Game | San Francisco 49ers vs. Los Angeles Chargers

Monday, Nov. 14

Commanders at Eagles (-11, 44)

Featured Game | Philadelphia Eagles vs. Washington Commanders

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